- 淇濆湥闆诲瓙榧籧Nose 鍦ㄦ灉閰掗ⅷ(f膿ng)鍛冲垎鏋愪腑鐨勬噳(y墨ng)鐢ㄧ爺绌�
- 鐧�(f膩)甯冩棩鏈燂細2025-03-21 鐎忚娆℃暩(sh霉)锛�222
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鏋滈厭甯傚牬(ch菐ng)杩戝勾渚�(l谩i)鐧�(f膩)灞曡繀閫�锛屽叾鐛�(d煤)鐗归ⅷ(f膿ng)鍛虫槸鍚稿紩娑堣不(f猫i)鑰呯殑闂�(gu膩n)閸靛洜绱犱箣涓�銆傛灉閰掗ⅷ(f膿ng)鍛冲彈鍘熸枡銆佺櫦(f膩)閰靛伐钘�銆佸劜(ch菙)瀛樻浠剁瓑澶氱ó鍥犵礌褰遍熆锛屾垚鍒嗗京(f霉)闆溿�傚偝绲�(t菕ng)鐨勬灉閰掗ⅷ(f膿ng)鍛冲垎鏋愭柟娉�锛屽鎰熷畼瑭�(p铆ng)鍍�(ji脿)渚濊炒浜哄伐涓昏鍒ゆ柗锛屽瓨鍦ㄥ��(g猫)楂斿樊鐣板ぇ銆佹晥鐜囦綆绛夊晱(w猫n)椤�锛涘寲瀛�(xu茅)鍒嗘瀽鏂规硶闆栬兘绮剧⒑妾㈡脯(c猫)鎴愬垎锛屼絾鎿嶄綔绻佺懀銆佹垚鏈珮銆傞浕瀛愰蓟浣滅偤涓�绋柊鍨嬫娓�(c猫)鎶�琛�(sh霉)锛屽叿鏈夊揩閫�銆佸瑙�銆侀噸寰�(f霉)鎬уソ绛夊劒(y艒u)榛�(di菐n)锛岃兘褰岃(b菙)鍌崇当(t菕ng)鏂规硶鐨勪笉瓒�锛屽湪鏋滈厭棰�(f膿ng)鍛冲垎鏋愰牁(l菒ng)鍩熷睍鐝�(xi脿n)鍑哄法澶ф經鍔�锛屽皪(du矛)鎻愬崌鏋滈厭鍝佽唱(zh矛)銆佸劒(y艒u)鍖栫敓鐢�(ch菐n)宸ヨ棟鍏锋湁閲嶈鎰忕京銆�
浜�銆佸(sh铆)椹�(y脿n)鏂规硶
2.1 瀵�(sh铆)椹�(y脿n)鏉愭枡
閬稿彇鏂囨獢涓彁鍙婄殑8绋灉閰�锛屽寘鎷�5绋憽钀勯厭锛堟柊鐤嗗崐骞�SJ銆佹硶鍦�(gu贸)鍗婄敎LS銆佹渤鍖楀共HY銆佽タ鐝墮骞�TJ銆佹硶鍦�(gu贸)骞�FT锛夈��1绋櫦(f膩)閰甸潚姊呴厭FZ銆�1绋棈(l谩n)鑾撻厭HZ浠ュ強1绋厤鍒堕潚姊呴厭LM銆傞�欎簺鏋滈厭娑佃搵浜嗕笉鍚屽師鏂欏拰鐢�(ch菐n)鍦帮紝鍏锋湁浠ｈ〃鎬�銆�
2.2 闆诲瓙榧�cNose妾㈡脯(c猫)
閲囩敤Super Nose闆诲瓙榧荤郴绲�(t菕ng)锛岃┎绯荤当(t菕ng)閰嶅倷14绋偝鎰熷櫒锛屽彲妾㈡脯(c猫)纭寲姘�佺～鍖栫墿銆侀唶椤�銆侀叜椤炪�侀啗椤炲拰鑺抽鍖栧悎鐗╃瓑澶氱ó棣欐埃鎴愬垎銆傚(sh铆)椹�(y脿n)鏅�(sh铆)锛屽彇10mL绋�閲嬪崄鍊嶇殑鏋滈厭妯ｅ搧缃簬50mL鐜荤拑灏忕摱涓�锛屽钩琛�60min浠ュ舰鎴愰爞绌�銆傞浕瀛愰蓟绯荤当(t菕ng)闋�(y霉)鐔�60min鍚�锛岃ō(sh猫)缃偝鎰熷櫒娓呮礂鏅�(sh铆)闁�100s銆侀噰妯ｉ枔闅�120s銆侀��(j矛n)妯ｉ�熺巼1L/min閫�(j矛n)琛屾娓�(c猫)锛屾娓�(c猫)绲�(ji茅)鏋滀互G/G90琛ㄧず锛屽嵆妯ｅ搧闆诲皫(d菐o)鐜囪垏娓呮綌绌烘埃闆诲皫(d菐o)鐜囦箣姣�銆�
2.3 鏁�(sh霉)鎿�(j霉)铏曠悊
閬�(y霉n)鐢ㄤ富鎴愬垎鍒嗘瀽锛�PCA锛夊拰鍋忔渶灏忎簩涔樻硶鍒ゅ垾鍒嗘瀽锛�PLS-DA锛夊皪(du矛)闆诲瓙榧�cNose妾㈡脯(c猫)鏁�(sh霉)鎿�(j霉)閫�(j矛n)琛岃檿鐞�銆�PCA鐢ㄤ簬闄嶄綆鏁�(sh霉)鎿�(j霉)缍害锛屽彲瑕栧寲涓嶅悓鏋滈厭妯ｅ搧闁撶殑宸暟锛�PLS-DA閫氶亷(gu貌)寤虹珛鍒ゅ垾妯″瀷锛岄��(j矛n)涓�姝ュ崁(q奴)鍒嗕笉鍚岄鍨嬬殑鏋滈厭锛岃⿻(p铆ng)浼版ā鍨嬬殑闋�(y霉)娓�(c猫)鑳藉姏鍜屽彲闈犳�с��
涓夈�佸(sh铆)椹�(y脿n)绲�(ji茅)鏋�
3.1 鍌虫劅鍣ㄩ熆鎳�(y墨ng)宸暟
闆烽仈(d谩)鍦栭’绀�锛屽偝鎰熷櫒S7-S13灏�(du矛)鎵�鏈夋ǎ鍝佺殑闊挎噳(y墨ng)姘村钩鐩歌繎锛�>0.01锛�锛岃�屽叾浠栧偝鎰熷櫒闊挎噳(y墨ng)宸暟椤憲锛�p<0.01锛�銆備緥濡�锛屾ǎ鍝�SJ鐨勯儴鍒嗗偝鎰熷櫒闊挎噳(y墨ng)杓冧綆锛�FT鍓囪純楂樸�傞�欒〃鏄庝笉鍚屾灉閰掍腑鎻櫦(f膩)鎬у寲鍚堢墿婵冨害涓嶅悓锛屽奖闊夸簡鍌虫劅鍣ㄩ熆鎳�(y墨ng)锛岄珨鐝�(xi脿n)鍑洪浕瀛愰蓟灏�(du矛)涓嶅悓鏋滈厭棰�(f膿ng)鍛崇殑鏁忔劅鎬�銆�
3.2 鏋滈厭鍗�(q奴)鍒嗚兘鍔�
PCA鍒嗘瀽绲�(ji茅)鏋滆〃鏄庯紝闆诲瓙榧绘暩(sh霉)鎿�(j霉)鐨勪富鎴愬垎鍒嗘瀽鑳借В閲嬬附鏂瑰樊鐨�92.1%锛�t[1]=80.2%锛�t[2]=11.9%锛�R²X(cum)=92.1%锛�Q²(cum)=27.3%锛�锛岃(shu艒)鏄庨浕瀛愰蓟鑳芥湁鏁堝崁(q奴)鍒嗕笉鍚屾灉閰�銆�PLS-DA妯″瀷椤ず鍑烘洿寮�(qi谩ng)鐨勮仛椤炴晥鏋滐紙R²X=0.994锛�R²Y=0.207锛�Q²=0.236锛�锛屼笖缍�(j墨ng)閬�(gu貌)200娆＄疆鎻涙椹�(y脿n)锛屾ā鍨嬪彲闈狅紙R²=0.0046锛�Q²=-0.079锛�銆傞�欐剰鍛宠憲闆诲瓙榧荤祼(ji茅)鍚�PLS-DA妯″瀷鍙簴(zh菙n)纰哄崁(q奴)鍒嗕笉鍚岄鍨嬫灉閰掋��
3.3 鑸囧叾浠栧垎鏋愭柟娉曠殑涓�鑷存��
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- 涓婁竴绡囷細涓婃捣淇濆湥闆诲瓙榧籧Nose锛氭灣娈煎搧璩�(zh矛)棰�(f膿ng)鍛崇爺绌剁殑闂�(gu膩n)閸靛姪鍔�
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琛屾キ(y猫)璩囪▕鎵�鍦ㄤ綅缃細棣栭爜(y猫) >> 琛屾キ(y猫)璩囪▕ >> 淇濆湥闆诲瓙榧籧Nose 鍦ㄦ灉閰掗ⅷ(f膿ng)鍛冲垎鏋愪腑鐨勬噳(y墨ng)鐢ㄧ爺绌�
